Gut and Liver (Jun 2010)

Hereditary Colon Cancer: Lynch Syndrome

DOI
https://doi.org/10.5009/gnl.2010.4.2.151
Journal volume & issue
Vol. 4, no. 2
pp. 151 – 160

Abstract

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Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is one important way to identify at-risk individuals. The elucidation of the molecular genetics of this syndrome has made it possible to screen for the disorder with molecular tests. Microsatellite instability and/or immunohistochemistry followed by germline testing for mutations in MMR genes is now a standard approach for clinically suspected cases. Correctly recognizing Lynch syndrome is essential for the application of appropriate screening and surveillance measures. Close surveillance and risk-reducing operations can decrease cancer-related mortality. In addition, counseling is an important component of the management of any family with Lynch syndrome. (Gut Liver 2010;4:151-160)

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