Evaluation of propylthiouracil effect on rat,s ovarian activity

Abstract

this study Evaluation the physiological activity effects of thyroid glands on the process of development and growth of ovaries and reproductive organs in rats.the study also investigates the adverse effects of antithyroid compounds adminidtered to mothers during lactation period on the developmental process of the newborn rat,s reproductive organs and the level of sexual hormones.the early and reversible hypothyroidism were induced in newborn rat,s viaPTU(propylthiouracil) solved in mothers, drinking water in order to study the development of reproductive organs.the results indicated a significant decrease(p0.01 and p<0.001 respectively),when compared to the control groups.the FSH serum density showed a decline up to the 35 days of life (p<0.01) and since then showed an upwared increase up to the 56 days of age(p<0.01).however the onset of puberty in treated animals was delayed.this may happen due to up-regulation phenomena.

Keywords

• propylthiouracil
• gonadotropine
• rat