Nature Communications (Feb 2022)

Cotranslational N-degron masking by acetylation promotes proteome stability in plants

  • Eric Linster,
  • Francy L. Forero Ruiz,
  • Pavlina Miklankova,
  • Thomas Ruppert,
  • Johannes Mueller,
  • Laura Armbruster,
  • Xiaodi Gong,
  • Giovanna Serino,
  • Matthias Mann,
  • Rüdiger Hell,
  • Markus Wirtz

DOI
https://doi.org/10.1038/s41467-022-28414-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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N-terminal protein acetylation is required for plant viability. Here the authors show that reducing N-terminal acetylation by NatA leads to an increase in global protein turnover that is facilitated by absent masking of a novel N-degron