Cancer Management and Research (Dec 2021)
Comparisons of Outcomes Between Adolescent and Young Adult with Older Patients After Radical Resection of Pancreatic Ductal Adenocarcinoma by Propensity Score Matching: A Single-Center Study
Abstract
Neng Tang,1,2 Xiaolin Dou,1,2 Xing You,1,2 Guodong Liu,1,2 Zhenglin Ou,1,2,* Hongyan Zai1,2,* 1Department of General Surgery, Xiangya Hospital Central South University, Changsha, 410008, Hunan Province, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, 410008, Hunan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhenglin Ou; Hongyan ZaiDepartment of General Surgery, Xiangya Hospital Central South University, 87 Xiangya Road, Changsha, 410008, Hunan Province, People’s Republic of ChinaEmail [email protected]; [email protected]: Adolescent and young adult (AYA) pancreatic ductal adenocarcinoma (PDAC) occurs in patients below 40 years old. Whether AYA patients have worse outcomes compared with older patients is still controversial. The purpose of this study is to compare the outcomes of AYA patients and older patients after radical surgery for PDAC.Methods: A single-center, retrospective, cohort study was conducted in patients who underwent radical surgery for PDAC in Xiangya Hospital Central South University from January 2007 to December 2019. The clinicopathological data and results of patients with PDAC were collected and analyzed retrospectively. They were divided into AYA group and older group based on age (< 40, AYA group; ≥ 40, older group). Based on all the considered covariates except age, we estimated 1:2 case propensity score matching (PSM).Results: A total of 1033 cases were enrolled, 46 cases (4.45%) in the AYA group. Both before and after PSM, the AYA patients have a higher preoperative CA19-9 than the older patients (P < 0.001) and (P < 0.001). Pathological results showed that AYA group had a higher microvascular invasion rate (P < 0.001 and P = 0.045) than older group. The median time of overall survival (OS) in AYA group and older group were 13 months (95% CI = 11.50– 14.50) and 14 months (95% CI = 13.50– 14.50), respectively. Additionally, AYA group have a worse 2-year OS rate than older group (8.70% vs 25.23%, P = 0.011 and 8.70% vs 25.00%, P = 0.023). According to the Log rank test, AYA group have a worse cumulative OS rate than older group (P = 0.002) and (P = 0.030), respectively.Conclusion: PDAC might be more aggressive in AYA, and the cumulative OS after radical PDAC surgery in AYA patients is worse than that in older patients.Keywords: adolescent and young adult, AYA, pancreatic ductal adenocarcinoma, PDAC, propensity score matching, PSM, total pancreaticoduodenectomy, TPD, overall survival, OS
