Influence and com pars ion intravenous Diazepam with intravenous midazolam as premedication in anesthesia on the saturation of arterial blood oxygen (1992)

Abstract

This research, which is semi- experimental is focused on the influence and comparison intravenous diazepam with intravenous midazolam as premedication in anesthesia on the saturation arterial blood oxygen before surgical operation, "pan patients who are in risk one under general anesthesia in the operating rooms of the hospitals affiliated to Iran University of Medical Sciences and Health services. Purposes of research A.General purposes: 1. Determine and compare the influence intravenous diazepam with intravenous midazolam as premedication in anesthesia on the saturation arterial blood oxygen before surgical operation upon patients who are in risk one under general anesthesia in the operating rooms of the hospitals affiliated to Iran University of Medical Sciences and Health Services. 2 Recommendations in order to use findings in anesthesia. 3. Recommendations in order to follow up studies. B.special aims: 1. Determine individual characteristics of patients. 2 Determine the influence of intravenous diazepam as premedication in anesthesia on the saturation arterial blood f'.U}'gen before surgical procedure , upon patients who (Ire in risk one under general anesthesia in the operating rooms of the hospitals affiliated to Iran University of Medical Sciences and Health services. 3. Determine influence of intravenous midazolam as premedication in anesthesia on the saturation arterial blood oxygen before surgical operation upon patients who are in risk one under general anesthesia in the operating rooms of the hospitals affiliated to Iran University of Medical Sciences and Health Services. 4. Comparsion of influence of intravenous diazepam with intravenous midazolam as premedication in anesthesia on the saturation arterial blood oxygen before surgical operation, upon patients who are in risk one under general anesthesia in the operating rooms of the hospitals affiliated of Iran University of Medical Sciences and Health services. Hypothesises of research: I . Saturation arterial blood oxygen 5 minutes after injection of intravenous diazepam differed with saturation arterial blood oxygen 5 minutes after injection of intravenous midazolam as premedication in anesthesia. 2 Saturation arterial blood oxygen 10 minutes after injection of intravenous diazepam differed with saturation arterial blood oxygen 10 minutes after injection of intravenous midazolam as premedication in anesthesia upon patients who are in risk one under general anesthesia. 3. Saturation arterial blood oxygen 15 minutes after injection of intravenous diazepam differed with saturation arterial blood oxygen 15 minutes after injection of intravenous midazotam as premedication in anesthesia upon patients who au in risk one under general anesthesia. 4. Saturation arterial blood oxygen before surgical operation after injection of intravenous diazepam differed with saturation arterial blood oxygen before surgical operation after injection of intravenous midasolam as premedication in anesthesia upon patients who are in risk one under general anesthesia. The limitation out of control of researcher: 1. Because of different individual characteristics every one has different reactions to drugs, which can affect the result of the research which is not under the control of the researcher. 2. Affected research sample with unknown disease somehow could influence the research result which is out of researcher control: 3. Different pasimu, position mind could influence research results out o[ researcher control There were 80 subjects used in thier research between the ages of 18 and 45 years old consistring of 37 women and 43 men, 0.2 mg/IV/kg diazepam was injected to first group and D.ll5 mg/W /kg was injected to control group before surgery. Outcome and research result companion incase of intravenous diazepam influence with intravenous midazolam as premedication on the saturation arterial blood oxygen before surgical operation, upon patients who art in risk one under general anesthesia has shown that both drugs decrease the saturation arterial blood oxygen but this reduction by midazolam is more pronounced. The statistical t test shown the meaningful relationship between first and second groups , in the first 5 minutes after premedication injection