Clinical, Cosmetic and Investigational Dermatology (Jan 2024)
Etanercept Combined with Glucocorticoid and Gamma Globulin for Treating Children with Toxic Epidermal Necrolysis: A Case Report
Abstract
Yanhua Fu,1 Yuanyuan Xiao,2 Tianji Gao,1 Junxiu Zhang,3 Tianjiao Wang1 1Department of Rheumatology, Baoding Hospital of Beijing Children’s Hospital, Baoding, 071000, People’s Republic of China; 2Department of Dermatology, National Center for Children’s Health (Beijing) Children’s Hospital Affiliated to Capital Medical University, Beijing, 100045, People’s Republic of China; 3Department of Dermatology, Baoding Hospital of Beijing Children’s Hospital, Baoding, 071000, People’s Republic of ChinaCorrespondence: Yuanyuan Xiao, Department of Dermatology, National Center for Children’s Health (Beijing) Children’s Hospital Affiliated to Capital Medical University, No. 56 of Nanlishi Road, Xicheng District, Beijing, 100045, People’s Republic of China, Tel +86 10 59612345, Email [email protected]: Toxic epidermal necrolysis (TEN) is a type of drug eruption in dermatology emergencies that is rare in clinical practice but has a high mortality rate. The main causes are drug and viral infections. Unfortunately, no expert consensus on treating this disease exists, and a standard therapy is absent. Up to now, glucocorticoids combined with gamma globulin are commonly used in clinical practice, but their efficacy is highly controversial. This study reports on a 7-year-old girl with TEN who did not respond to traditional therapy, such as methylprednisolone combined with gamma globulin, but was finally cured with an additional low-dose etanercept. The results showed that etanercept therapy in paediatric TEN is safe, reliable and worth recommending.Keywords: child toxic epidermal necrolysis, etanercept, glucocorticoids, gamma globulin
