Perbandingan Penyembuhan Luka Bakar Derajat Dua antara Rebusan Daun Sirih dan Moist Exposed Burn Ointment

Abstract

The use of topical agent is one of the main strategies in management of burn injury. At Dr. Hasan Sadikin Hospital, moist exposed burn ointment (MEBO) is the first line topical agent for treating burn injury, not all places in Indonesia able to use it. Piper betle is one of the traditional agent to treat wound including that caused burn injury. Our experimental study was to compare the second grade burn injury healing process by using Wistar sp. for boiled piper betle leaves, MEBO and as control physiologic sodium chloride for fourteen days (August 25th–September 8th 2009) at Animal Pharmacology Laboratory of Faculty of Medicine Padjadjaran University. The variables which measured were diameter of injury, pus development, evidence of serous and erythematous skin, at 4th, 7th and 14th day of studied. Histopathologic examination was conducted at day 14 to determine the amount of fibroblast, collagen and epithelial. The results according to the measurement of diameter (piper betle leaves group 17.4 mm) was smaller than other groups (p<0.001). In pus development control group was higher than other groups (p=0.043). In pathological findings, the control group was at inflammation phase, while in boiled piper betle leaves group was at proliferation phase and in MEBO group at remodeling phase (with epithel score 1.9 which higher than other groups (p<0.001)). In conclusions, application of boiled piper betle leaves in treating second degree burn injury gives a better result than physiologic sodium chloride, although MEBO is better for second degree burn injury healing process.

Keywords

• Moist exposed burn ointment
• piper betle
• second degree burn injury