Chemical Diversity and Biological Activities of <i>Phaeosphaeria</i> Fungi Genus: A Systematic Review

Abstract

Microbial natural products (MNPs) have been identified as important hotspots and effective sources for drug lead discovery. The genus Phaeosphaeria (family: Phaeosphaeriaceae, order: Pleosporales), in particular, has produced divergent chemical structures, including pyrazine alkaloids, isocoumarins, perylenequinones, anthraquinones, diterpenes, and cyclic peptides, which display a wide scope of biological potentialities. This contribution comprehensively highlights, over the period 1974⁻2018, the chemistry and biology of the isolated natural products from the micro-filamentous Phaeosphaeria fungi genus. A list of 71 compounds, with structural and biological diversities, were gathered into 5 main groups.

Keywords

• <i>Phaeosphaeria</i>
• pyrazine alkaloids
• polyketides
• isocoumarins
• perylenequinones
• anthraquinones
• cyclic peptides
• bioactivities