The CHD6 chromatin remodeler is an oxidative DNA damage response factor

Shaun Moore; N. Daniel Berger; Martijn S. Luijsterburg; Cortt G. Piett; Fintan K. T. Stanley; Christoph U. Schräder; Shujuan Fang; Jennifer A. Chan; David C. Schriemer; Zachary D. Nagel; Haico van Attikum; Aaron A. Goodarzi

doi:10.1038/s41467-018-08111-y

Nature Communications (Jan 2019)

The CHD6 chromatin remodeler is an oxidative DNA damage response factor

Shaun Moore,
N. Daniel Berger,
Martijn S. Luijsterburg,
Cortt G. Piett,
Fintan K. T. Stanley,
Christoph U. Schräder,
Shujuan Fang,
Jennifer A. Chan,
David C. Schriemer,
Zachary D. Nagel,
Haico van Attikum,
Aaron A. Goodarzi

Affiliations

Shaun Moore: Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary
N. Daniel Berger: Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary
Martijn S. Luijsterburg: Department of Human Genetics, Leiden University Medical Center
Cortt G. Piett: Harvard University, School of Public Health
Fintan K. T. Stanley: Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary
Christoph U. Schräder: Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary
Shujuan Fang: Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary
Jennifer A. Chan: Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary
David C. Schriemer: Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary
Zachary D. Nagel: Harvard University, School of Public Health
Haico van Attikum: Department of Human Genetics, Leiden University Medical Center
Aaron A. Goodarzi: Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary

DOI: https://doi.org/10.1038/s41467-018-08111-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

Read online

Oxidative DNA damage is associated with nucleosome respacing and transcriptional changes requiring chromatin remodeling enzymes. Here, the authors reveal that the CHD6 remodeler is a DNA damage response factor that relocates to damaged sites and promotes cell survival following oxidative damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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