Pulmonary pericytes regulate lung morphogenesis

Katsuhiro Kato; Rodrigo Diéguez-Hurtado; Do Young Park; Seon Pyo Hong; Sakiko Kato-Azuma; Susanne Adams; Martin Stehling; Britta Trappmann; Jeffrey L. Wrana; Gou Young Koh; Ralf H. Adams

doi:10.1038/s41467-018-04913-2

Nature Communications (Jun 2018)

Pulmonary pericytes regulate lung morphogenesis

Katsuhiro Kato,
Rodrigo Diéguez-Hurtado,
Do Young Park,
Seon Pyo Hong,
Sakiko Kato-Azuma,
Susanne Adams,
Martin Stehling,
Britta Trappmann,
Jeffrey L. Wrana,
Gou Young Koh,
Ralf H. Adams

Affiliations

Katsuhiro Kato: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine
Rodrigo Diéguez-Hurtado: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine
Do Young Park: Center for Vascular Research, Institute of Basic Science (IBS)
Seon Pyo Hong: Center for Vascular Research, Institute of Basic Science (IBS)
Sakiko Kato-Azuma: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine
Susanne Adams: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine
Martin Stehling: Electron Microscopy and Flow Cytometry Units, Max Planck Institute for Molecular Biomedicine
Britta Trappmann: Bioactive Materials Laboratory, Max Planck Institute for Molecular Biomedicine
Jeffrey L. Wrana: Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Gou Young Koh: Center for Vascular Research, Institute of Basic Science (IBS)
Ralf H. Adams: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine

DOI: https://doi.org/10.1038/s41467-018-04913-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Pericytes surround endothelial tubules and help maintain the integrity of blood vessels. Here the authors show that pericytes regulate lung morphogenesis via paracrine signalling controlled by components of the Hippo pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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