NK cells beat T cells at early breast cancer control

Abstract

Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8+ T cells. Our findings demonstrate that CD8+ T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in this setting.

Keywords

• hormonotherapy
• immune checkpoint blockers
• nicotinamide
• pd-1
• type i interferon
• tumor microenvironment