Nature Communications (Aug 2019)

Mycobacterial dynamin-like protein IniA mediates membrane fission

  • Manfu Wang,
  • Xiangyang Guo,
  • Xiuna Yang,
  • Bing Zhang,
  • Jie Ren,
  • Aijun Liu,
  • Yajun Ran,
  • Bing Yan,
  • Fang Chen,
  • Luke W. Guddat,
  • Junjie Hu,
  • Jun Li,
  • Zihe Rao

DOI
https://doi.org/10.1038/s41467-019-11860-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Tuberculosis drugs induce the expression of IniA, but so far little has been known about its structure and function. Here the authors present the apo and GTP bound crystal structures of Mycobacterium smegmatis IniA, which folds as a bacterial dynamin-like protein and show that IniA mediates membrane fission in vitro.