Discrete pH-Responsive Plasmonic Actuators via Site-Selective Encoding of Nanoparticles with DNA Triple Helix Motif

Kyle J. Gibson; Aleksander Prominski; Margaret S. Lee; Timothy M. Cronin; John Parker; Yossi Weizmann

Cell Reports Physical Science (Jun 2020)

Discrete pH-Responsive Plasmonic Actuators via Site-Selective Encoding of Nanoparticles with DNA Triple Helix Motif

Kyle J. Gibson,
Aleksander Prominski,
Margaret S. Lee,
Timothy M. Cronin,
John Parker,
Yossi Weizmann

Affiliations

Kyle J. Gibson: Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
Aleksander Prominski: Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
Margaret S. Lee: Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
Timothy M. Cronin: Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
John Parker: Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
Yossi Weizmann: Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA; Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; Corresponding author

Journal volume & issue: Vol. 1, no. 6
p. 100080

Abstract

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Summary: The synthesis of discrete nanoparticle self-assemblies has challenged the nanotechnology field for decades and has limited the study of nanoparticle interactions and the advance of nanomachinery. Here, we describe the preparation of discrete nanoparticle dimers from spherical gold nanoparticles and gold nanorods with stimuli-responsive optical properties as a result of site-specific DNA functionalization with an active triple helix motif. We present discrete assemblies using anisotropic nanoparticles that dynamically respond to changes in pH. Our approach to creating building blocks for nanoparticle self-assembly capable of creating discrete structures may allow for the future study of nanoparticle-nanoparticle interactions, plasmonic sensors, and nanoparticle-DNA hybrid nanomachinery.

Published in Cell Reports Physical Science

ISSN: 2666-3864 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Physics
Website: https://www.cell.com/cell-reports-physical-science

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