Nature Communications (Jun 2022)
Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study
- Thomas A. Auchtung,
- Christopher J. Stewart,
- Daniel P. Smith,
- Eric W. Triplett,
- Daniel Agardh,
- William A. Hagopian,
- Anette G. Ziegler,
- Marian J. Rewers,
- Jin-Xiong She,
- Jorma Toppari,
- Åke Lernmark,
- Beena Akolkar,
- Jeffrey P. Krischer,
- Kendra Vehik,
- Jennifer M. Auchtung,
- Nadim J. Ajami,
- Joseph F. Petrosino
Affiliations
- Thomas A. Auchtung
- Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Christopher J. Stewart
- Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Daniel P. Smith
- Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Eric W. Triplett
- Microbiology and Cell Science Department, Institute for Food and Agricultural Sciences, University of Florida
- Daniel Agardh
- Department of Clinical Sciences, Lund University Clinical Research Center, Skåne University Hospital
- William A. Hagopian
- Pacific Northwest Research Institute
- Anette G. Ziegler
- Institute of Diabetes Research, Helmholtz Zentrum München
- Marian J. Rewers
- Barbara Davis Center for Childhood Diabetes, University of Colorado
- Jin-Xiong She
- Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University
- Jorma Toppari
- Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku
- Åke Lernmark
- Department of Clinical Sciences, Lund University/CRC, Skane University Hospital
- Beena Akolkar
- National Institute of Diabetes & Digestive & Kidney Diseases
- Jeffrey P. Krischer
- Health Informatics Institute, Morsani College of Medicine, University of South Florida
- Kendra Vehik
- Health Informatics Institute, Morsani College of Medicine, University of South Florida
- Jennifer M. Auchtung
- Department of Food Science and Technology, University of Nebraska-Lincoln
- Nadim J. Ajami
- Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Joseph F. Petrosino
- Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-30686-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 8
Abstract
Here, via metagenomics and ITS2 sequencing analysis of children's stool samples from three months to four years, the authors show that the fungal composition changes and relative abundance increases at weaning, but unlike bacteria, the overall levels of fungal diversity do not change substantially over time.
