Transition-metal-free trifluoromethylthiolation–acylation of arynes by insertion into the C–S bonds

Abstract

An efficient procedure to access to ortho-SCF3 substituted benzophenones from arynes and trifluoromethylthioesters has been developed under transition-metal free conditions. This difunctionalization process involves the first insertion of arynes into the C–S σ-bonds to achieve vicinal trifluoromethylthiolation-acylation of arenes in one step.

Keywords

• Trifluoromethylthioesters
• Arynes
• Insertion reaction
• Trifluoromethylthiolation
• Acylation