Nature Communications (Jun 2020)
Nolz1 expression is required in dopaminergic axon guidance and striatal innervation
- Clement Soleilhavoup,
- Marco Travaglio,
- Kieran Patrick,
- Pedro Garção,
- Elangovan Boobalan,
- Youri Adolfs,
- Ruth V. Spriggs,
- Emma Moles-Garcia,
- Dalbir Dhiraj,
- Tony Oosterveen,
- Sarah L. Ferri,
- Ted Abel,
- Edward S. Brodkin,
- R. Jeroen Pasterkamp,
- Brian P. Brooks,
- Lia Panman
Affiliations
- Clement Soleilhavoup
- MRC Toxicology Unit, University of Cambridge, Hodgkin Building
- Marco Travaglio
- MRC Toxicology Unit, University of Cambridge, Hodgkin Building
- Kieran Patrick
- MRC Toxicology Unit, University of Cambridge, Hodgkin Building
- Pedro Garção
- MRC Toxicology Unit, University of Cambridge, Hodgkin Building
- Elangovan Boobalan
- Ophthalmic Genetics & Visual Function Branch, National Eye Institute, National Institutes of Health
- Youri Adolfs
- Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University
- Ruth V. Spriggs
- MRC Toxicology Unit, University of Cambridge, Hodgkin Building
- Emma Moles-Garcia
- MRC Toxicology Unit, University of Cambridge, Hodgkin Building
- Dalbir Dhiraj
- MRC Toxicology Unit, University of Cambridge, Hodgkin Building
- Tony Oosterveen
- MRC Toxicology Unit, University of Cambridge, Hodgkin Building
- Sarah L. Ferri
- Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa
- Ted Abel
- Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa
- Edward S. Brodkin
- Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania
- R. Jeroen Pasterkamp
- Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University
- Brian P. Brooks
- Ophthalmic Genetics & Visual Function Branch, National Eye Institute, National Institutes of Health
- Lia Panman
- MRC Toxicology Unit, University of Cambridge, Hodgkin Building
- DOI
- https://doi.org/10.1038/s41467-020-16947-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
The mechanisms regulating midbrain dopaminergic innervation during development are unclear. Here, the authors showed that Nolz1 is required for axonal guidance of dopaminergic neurons during embryonic development of the mouse brain.
