Frontiers in Genetics (Feb 2019)

Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal

  • Qiongqiong Wu,
  • Peiyao Li,
  • Minghua Wu,
  • Qiang Liu

DOI
https://doi.org/10.3389/fgene.2019.00016
Journal volume & issue
Vol. 10

Abstract

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CircRNAs (circular RNAs) are a class of RNAs generated from circularization with multiple novel functions. Recent studies have revealed the aberrant expression and aberrant functions of circRNAs in various tumors; thus, circRNAs have been recognized as promising cancer biomarkers. However, the underlying mechanisms behind their aberrant expression and functions remain unclear. In this review, we discuss at length the cancer-specific deregulation of circRNAs and the potential underlying aberrant events in circRNA biogenesis, localization and removal in cancer cells.

Keywords