Nature Communications (Jan 2020)
Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1
- Julia Minderjahn,
- Andreas Schmidt,
- Andreas Fuchs,
- Rudolf Schill,
- Johanna Raithel,
- Magda Babina,
- Christian Schmidl,
- Claudia Gebhard,
- Sandra Schmidhofer,
- Karina Mendes,
- Anna Ratermann,
- Dagmar Glatz,
- Margit Nützel,
- Matthias Edinger,
- Petra Hoffmann,
- Rainer Spang,
- Gernot Längst,
- Axel Imhof,
- Michael Rehli
Affiliations
- Julia Minderjahn
- Department of Internal Medicine III, University Hospital Regensburg
- Andreas Schmidt
- Biomedical Center, Protein Analysis Unit, Faculty of Medicine, Ludwig-Maximilians-Universität München
- Andreas Fuchs
- Biochemistry Centre Regensburg (BCR), University of Regensburg
- Rudolf Schill
- Statistical Bioinformatics Department, Institute of Functional Genomics, University of Regensburg
- Johanna Raithel
- Department of Internal Medicine III, University Hospital Regensburg
- Magda Babina
- Department of Dermatology and Allergy, Charité Universitätsmedizin Berlin
- Christian Schmidl
- Regensburg Center for Interventional Immunology (RCI), University Regensburg and University Medical Center Regensburg
- Claudia Gebhard
- Department of Internal Medicine III, University Hospital Regensburg
- Sandra Schmidhofer
- Department of Internal Medicine III, University Hospital Regensburg
- Karina Mendes
- Department of Internal Medicine III, University Hospital Regensburg
- Anna Ratermann
- Department of Internal Medicine III, University Hospital Regensburg
- Dagmar Glatz
- Department of Internal Medicine III, University Hospital Regensburg
- Margit Nützel
- Department of Internal Medicine III, University Hospital Regensburg
- Matthias Edinger
- Department of Internal Medicine III, University Hospital Regensburg
- Petra Hoffmann
- Department of Internal Medicine III, University Hospital Regensburg
- Rainer Spang
- Statistical Bioinformatics Department, Institute of Functional Genomics, University of Regensburg
- Gernot Längst
- Biochemistry Centre Regensburg (BCR), University of Regensburg
- Axel Imhof
- Biomedical Center, Protein Analysis Unit, Faculty of Medicine, Ludwig-Maximilians-Universität München
- Michael Rehli
- Department of Internal Medicine III, University Hospital Regensburg
- DOI
- https://doi.org/10.1038/s41467-019-13960-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
PU.1 is a master TF of hematopoietic lineage differentiation. Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1.
