lncRNA MALAT1 promotes HCC metastasis through the peripheral vascular infiltration via miRNA-613: a primary study using contrast ultrasound

Abstract

Highlights 1. Contrast-enhanced ultrasound (CEUS) grading was positively correlated with lncRNA MALAT1 in patients with hepatocellular carcinoma (HCC). 2. lncRNA MALAT1 expressed high and miRNA-613 expressed low in HCC tissues of patients with HCC. 3. lncRNA MALAT1 was targeted with miRNA-613. 4. Knocking down lncRNA MALAT1 could significantly increase miRNA-613 expression. 5. Knocking down lncRNA MALAT1 could reduce the migration of HCC cells. 6. Inhibiting miRNA-613 on the basis of knocking down lncRNA MALAT1 could increase the survival and migration of HCC cells.

Keywords

• Hepatocellular carcinoma
• Metastasis
• lncRNA MALAT1
• miRNA-613