Nature Communications (Dec 2018)

Impaired immune surveillance accelerates accumulation of senescent cells and aging

  • Yossi Ovadya,
  • Tomer Landsberger,
  • Hanna Leins,
  • Ezra Vadai,
  • Hilah Gal,
  • Anat Biran,
  • Reut Yosef,
  • Adi Sagiv,
  • Amit Agrawal,
  • Alon Shapira,
  • Joseph Windheim,
  • Michael Tsoory,
  • Reinhold Schirmbeck,
  • Ido Amit,
  • Hartmut Geiger,
  • Valery Krizhanovsky

DOI
https://doi.org/10.1038/s41467-018-07825-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Senescent cells accumulate with aging contributing to age-related disease and the role of the immune system in removing senescent cells is not completely understood. Here, the authors show that perforin deficient mice accumulate more senescent cells and have a shorter lifespan, and that this phenotype can be reversed with administration of a senolytic drug.