Dataset on inflammatory proteins expressions and sialic acid levels in apolipoprotein E-deficient mice with administration of N-acetylneuraminic acid and/or quercetin
Rongrong Dong,
Fahui Li,
Shucun Qin,
Yi Wang,
Yanhong Si,
Xuelian Xu,
Hua Tian,
Lei Zhai,
Guangjie Zhang,
Yongjun Li,
Yawei Zhou,
Ying Zhang,
Nan Zhang,
Shoudong Guo
Affiliations
Rongrong Dong
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Fahui Li
Department of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, China
Shucun Qin
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Yi Wang
Department of Ophthalmology, Affilated Hospital of Taishan Medical University, Taian 271000, China
Yanhong Si
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Xuelian Xu
School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Hua Tian
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Lei Zhai
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Guangjie Zhang
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Yongjun Li
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Yawei Zhou
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Ying Zhang
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Nan Zhang
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Shoudong Guo
Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China; Corresponding author. Fax: +86 0538 6225275.
The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-α, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice that are given a high-fat diet. Protein expression was performed by immunohistochemical imaging and NANA was quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) or semi-quantified using Image-Pro Plus software after ligation with fluorescein-5-thiosemicarbazide (FTSC). Further interpretation and discussion could be found at our research article entitled “Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice” (Guo et al., 2016) [1]. Keywords: Immunohistochemistry, LC-MS/MS, Sialic acid, Fluorescent labeling, Imaging
