Dataset on inflammatory proteins expressions and sialic acid levels in apolipoprotein E-deficient mice with administration of N-acetylneuraminic acid and/or quercetin

Rongrong Dong; Fahui Li; Shucun Qin; Yi Wang; Yanhong Si; Xuelian Xu; Hua Tian; Lei Zhai; Guangjie Zhang; Yongjun Li; Yawei Zhou; Ying Zhang; Nan Zhang; Shoudong Guo

Data in Brief (Sep 2016)

Dataset on inflammatory proteins expressions and sialic acid levels in apolipoprotein E-deficient mice with administration of N-acetylneuraminic acid and/or quercetin

Rongrong Dong,
Fahui Li,
Shucun Qin,
Yi Wang,
Yanhong Si,
Xuelian Xu,
Hua Tian,
Lei Zhai,
Guangjie Zhang,
Yongjun Li,
Yawei Zhou,
Ying Zhang,
Nan Zhang,
Shoudong Guo

Affiliations

Rongrong Dong: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Fahui Li: Department of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, China
Shucun Qin: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Yi Wang: Department of Ophthalmology, Affilated Hospital of Taishan Medical University, Taian 271000, China
Yanhong Si: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Xuelian Xu: School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Hua Tian: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Lei Zhai: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Guangjie Zhang: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Yongjun Li: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Yawei Zhou: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Ying Zhang: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Nan Zhang: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China
Shoudong Guo: Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian 271000, China; Corresponding author. Fax: +86 0538 6225275.

Journal volume & issue: Vol. 8
pp. 613 – 617

Abstract

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The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-α, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice that are given a high-fat diet. Protein expression was performed by immunohistochemical imaging and NANA was quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) or semi-quantified using Image-Pro Plus software after ligation with fluorescein-5-thiosemicarbazide (FTSC). Further interpretation and discussion could be found at our research article entitled “Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice” (Guo et al., 2016) [1]. Keywords: Immunohistochemistry, LC-MS/MS, Sialic acid, Fluorescent labeling, Imaging

Published in Data in Brief

ISSN: 2352-3409 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Science (General)
Website: http://www.journals.elsevier.com/data-in-brief/

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