International Journal of Biomedicine (Mar 2022)

Frequency of the Risk A Allele of rs17713054 Localized in the 3p21.31 COVID-19 Risk Locus in the Yakut Population

  • Nadezhda I. Pavlova,
  • Aleksey A. Bochurov,
  • Vladislav A. Alekseev,
  • Aleksandra T. Diakonova,
  • Vladimir V. Dodokhov,
  • Khariton A. Kurtanov

DOI
https://doi.org/10.21103/Article12(1)_OA19
Journal volume & issue
Vol. 12, no. 1
pp. 155 – 159

Abstract

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Background: Genome-wide association studies identified the region of chromosome 3p21.31 as having the strongest association with the severe COVID-19 and susceptibility to SARS-CoV-2 infection. The aim of our study was to investigate the frequency of the risk A allele of rs17713054 localized in the 3p21.31 COVID-19 risk locus in Yakuts. Methods and Results: A total of 382 DNA samples from healthy Yakut volunteers (184 men and 198 women; the average age of 41.8±0.05 years) were examined. Our results show that the frequency of the risk A allele of the rs17713054 SNP in the Yakut population occurs at a frequency of 2% and generally corresponds to the frequency of East Asian populations (from 0% to 2%), geographically close to the Yakuts and belonging to the same Mongoloid race.

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