Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304
Ghada Attia,
Aïda Mascret,
Chouki Zerrouki,
Najla Fourati,
Maité Sylla-Iyarreta Veitía,
Marc Port
Affiliations
Ghada Attia
Laboratoire SATIE, UMR CNRS 8029, Conservatoire National des Arts et Métiers (Cnam), 292 rue Saint Martin, HESAM Université, Paris 75003, France
Aïda Mascret
Equipe de Chimie Moléculaire du Laboratoire Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Conservatoire National des Arts et Métiers (Cnam), 2 rue Conté, HESAM Université, Paris 75003, France; Peptinov, Pépinière Cochin Santé, Hôpital Cochin, 29 rue du Faubourg Saint Jacques, Paris 75014, France
Chouki Zerrouki
Laboratoire SATIE, UMR CNRS 8029, Conservatoire National des Arts et Métiers (Cnam), 292 rue Saint Martin, HESAM Université, Paris 75003, France
Najla Fourati
Laboratoire SATIE, UMR CNRS 8029, Conservatoire National des Arts et Métiers (Cnam), 292 rue Saint Martin, HESAM Université, Paris 75003, France; Corresponding authors.
Maité Sylla-Iyarreta Veitía
Equipe de Chimie Moléculaire du Laboratoire Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Conservatoire National des Arts et Métiers (Cnam), 2 rue Conté, HESAM Université, Paris 75003, France; Corresponding authors.
Marc Port
Equipe de Chimie Moléculaire du Laboratoire Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Conservatoire National des Arts et Métiers (Cnam), 2 rue Conté, HESAM Université, Paris 75003, France; Corresponding authors.
The data presented here are related to the article entitled “New contributions to the drug profile of TNFα inhibitor SPD304: affinity, selectivity ADMET considerations” published in the European Journal of pharmacology. As DMSO is usually used as a co-solvent to dissolve low aqueous soluble small molecules, such as SPD304, we have investigated the influence of its concentration on the kinetic of interaction between tumor necrosis factor α (TNF-α) and its inhibitor, SPD304. The presented data, acquired using a surface acoustic wave sensor, can be used in further biological studies to compare the kinetic of interaction between proteins/small molecules in general and TNFα/inhibitors in particular. The estimated dissociation constant can be compared to other ones to statute on the degree of affinity between a protein and a given molecule.
