INNs granted with specific storage requirements in Bulgarian pharmacies. Part 1: Medicines acting on cardiovascular and nervous system

Abstract

Some medicines require special storage in Bulgarian pharmacies due to serious adverse reactions that may be even life-threatening. They are listed in Appendix № 9 to Art. 17, para. 1 of Ordinance № 28 of 9th December 2008, issued by the Minister of Health. The appendix includes 70 medicines from different pharmacotherapeutic groups and with various pharmacological effects. The performed documentary data analysis showed that a major part of these medicines are not registered for use by the Bulgarian Drug Agency to date. In addition, there are a number of medications that have a marketing authorization for use in Bulgaria but are not listed in this specific Appendix, although they belong to the same pharmacotherapeutic group and exert the same pharmacologic action as some included medicines. In conclusion, due to these inconsistencies, it remains unclear whether the Appendix is up to date or needs to be updated.