Nature Communications (Jun 2020)
The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis
- Qikun Liu,
- Sylvain Bischof,
- C. Jake Harris,
- Zhenhui Zhong,
- Lingyu Zhan,
- Calvin Nguyen,
- Andrew Rashoff,
- William D. Barshop,
- Fei Sun,
- Suhua Feng,
- Magdalena Potok,
- Javier Gallego-Bartolome,
- Jixian Zhai,
- James A. Wohlschlegel,
- Michael F. Carey,
- Jeffrey A. Long,
- Steven E. Jacobsen
Affiliations
- Qikun Liu
- School of Advanced Agricultural Sciences, Peking University
- Sylvain Bischof
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- C. Jake Harris
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- Zhenhui Zhong
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- Lingyu Zhan
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- Calvin Nguyen
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- Andrew Rashoff
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- William D. Barshop
- Department of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles
- Fei Sun
- Department of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles
- Suhua Feng
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- Magdalena Potok
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- Javier Gallego-Bartolome
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- Jixian Zhai
- Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology
- James A. Wohlschlegel
- Department of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles
- Michael F. Carey
- Department of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles
- Jeffrey A. Long
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- Steven E. Jacobsen
- Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
- DOI
- https://doi.org/10.1038/s41467-020-16651-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Mediator is a multiprotein complex required to activate gene transcription by RNAPII. Here, the authors report that MED12 and MED13 are conditional positive regulators that facilitate the expression of genes depleted in active chromatin marks and the induction of gene expression in response to environmental stimuli in Arabidopsis.
