Nature Communications (Apr 2022)
STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming
- Zhaowei Chu,
- Lei Gu,
- Yeguang Hu,
- Xiaoyang Zhang,
- Man Li,
- Jiajia Chen,
- Da Teng,
- Man Huang,
- Che-Hung Shen,
- Li Cai,
- Toshimi Yoshida,
- Yifeng Qi,
- Zhixin Niu,
- Austin Feng,
- Songmei Geng,
- Dennie T. Frederick,
- Emma Specht,
- Adriano Piris,
- Ryan J. Sullivan,
- Keith T. Flaherty,
- Genevieve M. Boland,
- Katia Georgopoulos,
- David Liu,
- Yang Shi,
- Bin Zheng
Affiliations
- Zhaowei Chu
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School
- Lei Gu
- Epigenetics Laboratory, Max Planck Institute for Heart and Lung Research
- Yeguang Hu
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School
- Xiaoyang Zhang
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Man Li
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School
- Jiajia Chen
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Da Teng
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School
- Man Huang
- Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School
- Che-Hung Shen
- National Institute of Cancer Research, National Health Research Institutes
- Li Cai
- Department of Cancer Biology, University of Texas MD Anderson Cancer Center
- Toshimi Yoshida
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School
- Yifeng Qi
- Department of Chemistry, Massachusetts Institute of Technology
- Zhixin Niu
- Epigenetics Laboratory, Max Planck Institute for Heart and Lung Research
- Austin Feng
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School
- Songmei Geng
- Department of Dermatology, The Second Hospital Affiliated to Xi’an Jiaotong University
- Dennie T. Frederick
- Department of Medicine, Massachusetts General Hospital Cancer Center
- Emma Specht
- Department of Medicine, Massachusetts General Hospital Cancer Center
- Adriano Piris
- Department of Dermatology, Brigham and Women’s Hospital and Harvard Medical School
- Ryan J. Sullivan
- Department of Medicine, Massachusetts General Hospital Cancer Center
- Keith T. Flaherty
- Department of Medicine, Massachusetts General Hospital Cancer Center
- Genevieve M. Boland
- Department of Surgical Oncology, Massachusetts General Hospital
- Katia Georgopoulos
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School
- David Liu
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Yang Shi
- Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School
- Bin Zheng
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-29541-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
STAG2 is a core subunit of the cohesin complex involved in DNA looping, but its transcriptional targets are largely unknown. Here the authors show STAG2 controls the 3D chromatin structure at the IRF9 locus to restrict IRF9 expression. Loss of STAG2 results in IRF9 activation, which in turn upregulates PD-L1 expression in cancer cells, suggesting a tumor suppressor function in immune evasion.
