Nature Communications (Nov 2022)

Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster

  • Kerry J. Laing,
  • Werner J. D. Ouwendijk,
  • Victoria L. Campbell,
  • Christopher L. McClurkan,
  • Shahin Mortazavi,
  • Michael Elder Waters,
  • Maxwell P. Krist,
  • Richard Tu,
  • Nhi Nguyen,
  • Krithi Basu,
  • Congrong Miao,
  • D. Scott Schmid,
  • Christine Johnston,
  • Georges M. G. M. Verjans,
  • David M. Koelle

DOI
https://doi.org/10.1038/s41467-022-34698-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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T cells are considered important for controlling skin infections. Here, the authors report that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in rash-involved skin after recovery from zoster.