Nature Communications (Oct 2022)
XPF activates break-induced telomere synthesis
- Chia-Yu Guh,
- Hong-Jhih Shen,
- Liv WeiChien Chen,
- Pei-Chen Chiu,
- I-Hsin Liao,
- Chen-Chia Lo,
- Yunfei Chen,
- Yu-Hung Hsieh,
- Ting-Chia Chang,
- Chien-Ping Yen,
- Yi-Yun Chen,
- Tom Wei-Wu Chen,
- Liuh-Yow Chen,
- Ching-Shyi Wu,
- Jean-Marc Egly,
- Hsueh-Ping Catherine Chu
Affiliations
- Chia-Yu Guh
- Institute of Molecular and Cellular Biology, National Taiwan University
- Hong-Jhih Shen
- Institute of Molecular and Cellular Biology, National Taiwan University
- Liv WeiChien Chen
- Institute of Molecular and Cellular Biology, National Taiwan University
- Pei-Chen Chiu
- Institute of Molecular and Cellular Biology, National Taiwan University
- I-Hsin Liao
- Institute of Molecular and Cellular Biology, National Taiwan University
- Chen-Chia Lo
- Institute of Molecular and Cellular Biology, National Taiwan University
- Yunfei Chen
- Institute of Molecular and Cellular Biology, National Taiwan University
- Yu-Hung Hsieh
- Institute of Molecular and Cellular Biology, National Taiwan University
- Ting-Chia Chang
- Institute of Molecular and Cellular Biology, National Taiwan University
- Chien-Ping Yen
- Institute of Molecular and Cellular Biology, National Taiwan University
- Yi-Yun Chen
- Institute of Biological Chemistry, Academia Sinica
- Tom Wei-Wu Chen
- Department of Oncology, National Taiwan University Hospital and Graduate Institute of Oncology, National Taiwan University College of Medicine
- Liuh-Yow Chen
- Institute of Molecular Biology, Academia Sinica
- Ching-Shyi Wu
- Department of Pharmacology, National Taiwan University
- Jean-Marc Egly
- Department of Functional Genomics and Cancer, IGBMC, CNRS/INSERM/University of Strasbourg
- Hsueh-Ping Catherine Chu
- Institute of Molecular and Cellular Biology, National Taiwan University
- DOI
- https://doi.org/10.1038/s41467-022-33428-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend their telomeres independent of telomerase.
