Кубанский научный медицинский вестник (Dec 2014)

Prognostic significance of genetic factors in the development of proliferative diseases of the uterus

  • V. A. Khorolsky,
  • I. M. Ordiyants,
  • V. V. Kardanova,
  • Y. O. Stykin

Journal volume & issue
no. 6
pp. 90 – 94

Abstract

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Were studied reproductive health of 200 women aged from 18 to 48 years, of which 64 with fibroids, 33 - with fibroids in combination with adenomyosis and 103 - without fibroids and adenomyosis. Performed genotyping of six molecular genetic markers (SNPs-351A/G and -397 T/S ESRa gene, a polymorphic marker genes of tumor necrosis factor a receptor tumor necrosis factor 1-St and 2-nd type and lymphotoxin a) to study the role of family history in the formation of fibroids in the uterus in women. Women with genotypes GG, GA, AA polymorphism +36 A/G receptor tumor necrosis factor 1 and type GG polymorphism +250 G/A lymphotoxin a are increased risk of developing uterine fibroids and adenomyosis.

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