Evaluation of structural-functional changes of the left ventricular myocardium in patients with arterial hypertension and obesity by the level of irisin

Abstract

The aim was to evaluate the structural and functional changes of the left ventricular myocardium according to the data of echocardiography in patients with arterial hypertension combined with obesity by the level of irisin. Materials and methods. 105 patients were divided into 2 groups for participation in the study: the 1 group consisted of patients with arterial hypertension with concomitant obesity with concomitant obesity (n = 70), the group 2 – patients with arterial hypertension and normal body weight (n = 35). The control group consisted of 25 practically healthy persons. All participants of the study underwent irisin level measurement by an enzyme-linked immuno-sorbent assay and an echocardiographic examination with subsequent computer processing of the results using the software package “Statistica 6.0” (StatSoft Inc.,USA). Results. In patients with arterial hypertension and obesity, hypoirisinemia (irisin level <1.19 ± 0.03 ng/ml) was associated with an increase in the end-diastolic and systolic volumes by 31.57 % (r = -0.44; Р < 0. 05) and 20.70 % (r = -0.53; P <0.05), sizes – by 43.54 % (r = -0.36; P < 0.05) and 40.44 % (r = -0.62; P < 0.05) and decrease in the ejection fraction by 16.59 % (r = 0.41; P < 0.05) (P < 0.05). Conclusions. Decrease in the content of serum irisin leads to structural and functional changes in the left ventricular myocardium in the form of myocardial contractility reduction and increase in both the cavity and size of the left ventricle, and can play a role in the pathogenesis of obesity in patients with arterial hypertension.

Keywords

• hypertension
• obesity
• irisin
• haemodynamics