Multicentric Castleman's disease: Report of three cases

M. Guazzaroni, MD PhD; F. Bocchinfuso, MD; E. Vasili, MD; A. Lacchè, MD; T. Ranalli, MD; A. Garipoli, MD; F. Di Tosto, MD; R. Floris, MD PhD

Radiology Case Reports (Mar 2019)

Multicentric Castleman's disease: Report of three cases

M. Guazzaroni, MD PhD,
F. Bocchinfuso, MD,
E. Vasili, MD,
A. Lacchè, MD,
T. Ranalli, MD,
A. Garipoli, MD,
F. Di Tosto, MD,
R. Floris, MD PhD

Affiliations

M. Guazzaroni, MD PhD: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, Italy
F. Bocchinfuso, MD: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, Italy
E. Vasili, MD: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, Italy
A. Lacchè, MD: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, Italy
T. Ranalli, MD: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, Italy
A. Garipoli, MD: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, Italy
F. Di Tosto, MD: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, Italy
R. Floris, MD PhD: Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, Italy

Journal volume & issue: Vol. 14, no. 3
pp. 328 – 332

Abstract

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Castleman's disease is an uncommon benign B-cell lymphoproliferative disorder. According to lymph nodes distribution, there are two distinct subtypes of disease: unicentric and multicentric. Unicentric Castleman's disease is more common, localized to one site, and locally treated. On the contrary, multicentric form is a rare systemic disease characterized by diffuse lymphadenopathy and inflammatory symptoms. We report three cases of persons that were initially suspected to have a lymphoma but were later histologically confirmed to have Multicentric Castleman's Disease. In addition, our work aims to investigate the role of fluorodeoxyglucose (FDG) PET/CT in evaluation of this rare condition. Keywords: Multicentric Castleman's disease, Hyaline vascular type, FDG PET/CT

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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