Nature Communications (Dec 2016)
The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity
- Damya Laoui,
- Jiri Keirsse,
- Yannick Morias,
- Eva Van Overmeire,
- Xenia Geeraerts,
- Yvon Elkrim,
- Mate Kiss,
- Evangelia Bolli,
- Qods Lahmar,
- Dorine Sichien,
- Jens Serneels,
- Charlotte L. Scott,
- Louis Boon,
- Patrick De Baetselier,
- Massimiliano Mazzone,
- Martin Guilliams,
- Jo A. Van Ginderachter
Affiliations
- Damya Laoui
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Jiri Keirsse
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Yannick Morias
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Eva Van Overmeire
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Xenia Geeraerts
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Yvon Elkrim
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Mate Kiss
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Evangelia Bolli
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Qods Lahmar
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Dorine Sichien
- Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
- Jens Serneels
- Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
- Charlotte L. Scott
- Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
- Louis Boon
- Epirus Biopharmaceuticals NL
- Patrick De Baetselier
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- Massimiliano Mazzone
- Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
- Martin Guilliams
- Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
- Jo A. Van Ginderachter
- Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center
- DOI
- https://doi.org/10.1038/ncomms13720
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
Dendritic cells are antigen-presenting cells consisting of distinct subsets originating from different lineages. Here, the authors identify the subsets of dendritic cells populating the tumour tissue in both mice and humans and find they have opposing functions in regulating the anti-tumour immune response.
