Communications Biology (Apr 2022)
An Amish founder population reveals rare-population genetic determinants of the human lipidome
- May E. Montasser,
- Stella Aslibekyan,
- Vinodh Srinivasasainagendra,
- Hemant K. Tiwari,
- Amit Patki,
- Minoo Bagheri,
- Tobias Kind,
- Dinesh Kumar Barupal,
- Sili Fan,
- James Perry,
- Kathleen A. Ryan,
- Alan R. Shuldiner,
- Donna K. Arnett,
- Amber L. Beitelshees,
- Marguerite Ryan Irvin,
- Jeffrey R. O’Connell
Affiliations
- May E. Montasser
- Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine
- Stella Aslibekyan
- Department of Epidemiology, University of Alabama at Birmingham
- Vinodh Srinivasasainagendra
- Department of Epidemiology, University of Alabama at Birmingham
- Hemant K. Tiwari
- Department of Epidemiology, University of Alabama at Birmingham
- Amit Patki
- Department of Epidemiology, University of Alabama at Birmingham
- Minoo Bagheri
- Department of Epidemiology, University of Alabama at Birmingham
- Tobias Kind
- West Coast Metabolomics Center
- Dinesh Kumar Barupal
- West Coast Metabolomics Center
- Sili Fan
- West Coast Metabolomics Center
- James Perry
- Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine
- Kathleen A. Ryan
- Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine
- Alan R. Shuldiner
- Regeneron Genetics Center, LLC.
- Donna K. Arnett
- Department of Epidemiology, University of Kentucky
- Amber L. Beitelshees
- Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine
- Marguerite Ryan Irvin
- Department of Epidemiology, University of Alabama at Birmingham
- Jeffrey R. O’Connell
- Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine
- DOI
- https://doi.org/10.1038/s42003-022-03291-2
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
A GWAS of 355 lipid species in the Old Order Amish founder population reveals associations between Amish-enriched loci and several sphingolipids.
