Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances

Eva Puchľová; Thomas Hilberath; Kvetoslava Vranková; Frank Hollmann

doi:10.3389/fctls.2022.926316

Frontiers in Catalysis (Jun 2022)

Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances

Eva Puchľová,
Thomas Hilberath,
Kvetoslava Vranková,
Frank Hollmann

Affiliations

Eva Puchľová: Axxence Slovakia s.r.o, Bratislava, Slovakia
Thomas Hilberath: Department of Biotechnology, Delft University of Technology, Delft, Netherlands
Kvetoslava Vranková: Axxence Slovakia s.r.o, Bratislava, Slovakia
Frank Hollmann: Department of Biotechnology, Delft University of Technology, Delft, Netherlands

DOI: https://doi.org/10.3389/fctls.2022.926316
Journal volume & issue: Vol. 2

Abstract

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Non-enantioselective alcohol dehydrogenases (ADHs) are rarely found in the biocatalysis portfolio. Generally, highly enantioselective ADHs are sought for. Using such ADHs for the oxidation of racemic alcohols generally results in a kinetic resolution of the starting material, which is unfavourable if the ketone represents the product of interest. In the current contribution we report the ADH from Sphingobium yanoikuyae (SyADH) as non-enantioselective ADH for the complete oxidation or rac-heptan-2-ol (representing further 2-alkanols).

Published in Frontiers in Catalysis

ISSN: 2673-7841 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.frontiersin.org/journals/catalysis

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