Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies

Emmanuelle V. LeBlanc; Youjin Kim; Chantelle J. Capicciotti; Che C. Colpitts

doi:10.3390/pathogens10060685

Pathogens (Jun 2021)

Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies

Emmanuelle V. LeBlanc,
Youjin Kim,
Chantelle J. Capicciotti,
Che C. Colpitts

Affiliations

Emmanuelle V. LeBlanc: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada
Youjin Kim: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada
Chantelle J. Capicciotti: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada
Che C. Colpitts: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada

DOI: https://doi.org/10.3390/pathogens10060685
Journal volume & issue: Vol. 10, no. 6
p. 685

Abstract

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Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glycan-dependent interactions are crucial to many aspects of the highly complex HCV entry process, and also modulate immune evasion. This review provides an overview of the roles of viral and cellular glycans in HCV infection and highlights glycan-focused advances in the development of entry inhibitors and vaccines to effectively prevent HCV infection.

Published in Pathogens

ISSN: 2076-0817 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/pathogens

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Abstract

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