Nature Communications (Jun 2021)
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
- Nils C. Gassen,
- Jan Papies,
- Thomas Bajaj,
- Jackson Emanuel,
- Frederik Dethloff,
- Robert Lorenz Chua,
- Jakob Trimpert,
- Nicolas Heinemann,
- Christine Niemeyer,
- Friderike Weege,
- Katja Hönzke,
- Tom Aschman,
- Daniel E. Heinz,
- Katja Weckmann,
- Tim Ebert,
- Andreas Zellner,
- Martina Lennarz,
- Emanuel Wyler,
- Simon Schroeder,
- Anja Richter,
- Daniela Niemeyer,
- Karen Hoffmann,
- Thomas F. Meyer,
- Frank L. Heppner,
- Victor M. Corman,
- Markus Landthaler,
- Andreas C. Hocke,
- Markus Morkel,
- Nikolaus Osterrieder,
- Christian Conrad,
- Roland Eils,
- Helena Radbruch,
- Patrick Giavalisco,
- Christian Drosten,
- Marcel A. Müller
Affiliations
- Nils C. Gassen
- Department of Psychiatry and Psychotherapy, University of Bonn, Medical Faculty
- Jan Papies
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Thomas Bajaj
- Department of Psychiatry and Psychotherapy, University of Bonn, Medical Faculty
- Jackson Emanuel
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Frederik Dethloff
- Max Planck Institute for Biology of Ageing
- Robert Lorenz Chua
- Center for Digital Health, Berlin Institute of Health (BIH) and Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Jakob Trimpert
- Institute of Virology, Freie Universität Berlin
- Nicolas Heinemann
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Christine Niemeyer
- Department of Psychiatry and Psychotherapy, University of Bonn, Medical Faculty
- Friderike Weege
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Katja Hönzke
- Molecular Imaging of Immunoregulation, Medizinische Klinik m.S. Infektiologie & Pneumologie, Charité-Universitätsmedizin Berlin
- Tom Aschman
- Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Daniel E. Heinz
- Department of Psychiatry and Psychotherapy, University of Bonn, Medical Faculty
- Katja Weckmann
- Department of Psychiatry and Psychotherapy, University of Bonn, Medical Faculty
- Tim Ebert
- Department of Psychiatry and Psychotherapy, University of Bonn, Medical Faculty
- Andreas Zellner
- Department of Psychiatry and Psychotherapy, University of Bonn, Medical Faculty
- Martina Lennarz
- Department of Psychiatry and Psychotherapy, University of Bonn, Medical Faculty
- Emanuel Wyler
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
- Simon Schroeder
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Anja Richter
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Daniela Niemeyer
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Karen Hoffmann
- Molecular Imaging of Immunoregulation, Medizinische Klinik m.S. Infektiologie & Pneumologie, Charité-Universitätsmedizin Berlin
- Thomas F. Meyer
- Laboratory of Infection Oncology, Institute of Clinical Molecular Biology, UKSH, Christian Albrechts University of Kiel
- Frank L. Heppner
- Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Victor M. Corman
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Markus Landthaler
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
- Andreas C. Hocke
- Molecular Imaging of Immunoregulation, Medizinische Klinik m.S. Infektiologie & Pneumologie, Charité-Universitätsmedizin Berlin
- Markus Morkel
- Institute for Pathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Nikolaus Osterrieder
- Institute of Virology, Freie Universität Berlin
- Christian Conrad
- Center for Digital Health, Berlin Institute of Health (BIH) and Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Roland Eils
- Center for Digital Health, Berlin Institute of Health (BIH) and Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Helena Radbruch
- Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Patrick Giavalisco
- Max Planck Institute for Biology of Ageing
- Christian Drosten
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Marcel A. Müller
- Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- DOI
- https://doi.org/10.1038/s41467-021-24007-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
