Nature Communications (Jun 2021)
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
- Monisha Samuel,
- Pamali Fonseka,
- Rahul Sanwlani,
- Lahiru Gangoda,
- Sing Ho Chee,
- Shivakumar Keerthikumar,
- Alex Spurling,
- Sai V. Chitti,
- Damien Zanker,
- Ching-Seng Ang,
- Ishara Atukorala,
- Taeyoung Kang,
- Sanjay Shahi,
- Akbar L. Marzan,
- Christina Nedeva,
- Claire Vennin,
- Morghan C. Lucas,
- Lesley Cheng,
- David Herrmann,
- Mohashin Pathan,
- David Chisanga,
- Sean C. Warren,
- Kening Zhao,
- Nidhi Abraham,
- Sushma Anand,
- Stephanie Boukouris,
- Christopher G. Adda,
- Lanzhou Jiang,
- Tanmay M. Shekhar,
- Nikola Baschuk,
- Christine J. Hawkins,
- Amelia J. Johnston,
- Jacqueline Monique Orian,
- Nicholas J. Hoogenraad,
- Ivan K. Poon,
- Andrew F. Hill,
- Markandeya Jois,
- Paul Timpson,
- Belinda S. Parker,
- Suresh Mathivanan
Affiliations
- Monisha Samuel
- Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University
- Pamali Fonseka
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Rahul Sanwlani
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Lahiru Gangoda
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Sing Ho Chee
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Shivakumar Keerthikumar
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Alex Spurling
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Sai V. Chitti
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Damien Zanker
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Ching-Seng Ang
- Bio21 Institute, University of Melbourne
- Ishara Atukorala
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Taeyoung Kang
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Sanjay Shahi
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Akbar L. Marzan
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Christina Nedeva
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Claire Vennin
- Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales
- Morghan C. Lucas
- Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales
- Lesley Cheng
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- David Herrmann
- Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales
- Mohashin Pathan
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- David Chisanga
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Sean C. Warren
- Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales
- Kening Zhao
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Nidhi Abraham
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Sushma Anand
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Stephanie Boukouris
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Christopher G. Adda
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Lanzhou Jiang
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Tanmay M. Shekhar
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Nikola Baschuk
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Christine J. Hawkins
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Amelia J. Johnston
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Jacqueline Monique Orian
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Nicholas J. Hoogenraad
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Ivan K. Poon
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Andrew F. Hill
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Markandeya Jois
- Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University
- Paul Timpson
- Garvan Institute of Medical Research, The Kinghorn Cancer Centre & St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales
- Belinda S. Parker
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Suresh Mathivanan
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- DOI
- https://doi.org/10.1038/s41467-021-24273-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Dietary extracellular vesicles (EVs) could potentially be absorbed by the intestinal tract of the host and exert multiple phenotypic changes. Here, the authors isolate and characterize EVs from raw and commercial bovine milk and show orally administered EVs to have a context specific role in promoting or suppressing primary tumor growth and metastasis in multiple mouse tumor models.
