Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics

Tejasvi Dudiki; Julia Meller; Gautam Mahajan; Huan Liu; Irina Zhevlakova; Samantha Stefl; Conner Witherow; Eugene Podrez; Chandrasekhar R. Kothapalli; Tatiana V. Byzova

doi:10.1038/s41467-020-14787-y

Nature Communications (Feb 2020)

Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics

Tejasvi Dudiki,
Julia Meller,
Gautam Mahajan,
Huan Liu,
Irina Zhevlakova,
Samantha Stefl,
Conner Witherow,
Eugene Podrez,
Chandrasekhar R. Kothapalli,
Tatiana V. Byzova

Affiliations

Tejasvi Dudiki: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic
Julia Meller: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic
Gautam Mahajan: Chemical and Biomedical Engineering Department, Washkewicz College of Engineering, Cleveland State University
Huan Liu: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic
Irina Zhevlakova: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic
Samantha Stefl: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic
Conner Witherow: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic
Eugene Podrez: Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic
Chandrasekhar R. Kothapalli: Chemical and Biomedical Engineering Department, Washkewicz College of Engineering, Cleveland State University
Tatiana V. Byzova: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic

DOI: https://doi.org/10.1038/s41467-020-14787-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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During development and pathologies of the central nervous system, blood vessels are closely connected with the innate immune cells, microglia. Here, the authors report that microglia adjust their angiogenic program to shape blood vessels and may depend on tissue stiffness.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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