Nature Communications (Dec 2018)

A quasi-integral controller for adaptation of genetic modules to variable ribosome demand

  • Hsin-Ho Huang,
  • Yili Qian,
  • Domitilla Del Vecchio

DOI
https://doi.org/10.1038/s41467-018-07899-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Competition for shared cellular resources often renders genetic circuits poorly predictable. Here the authors design a biomolecular quasi-integral controller that allows gene expression to adapt to variable demand in translation resources.