Nature Communications (Sep 2020)

Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila

  • Bumsik Cho,
  • Sang-Ho Yoon,
  • Daewon Lee,
  • Ferdinand Koranteng,
  • Sudhir Gopal Tattikota,
  • Nuri Cha,
  • Mingyu Shin,
  • Hobin Do,
  • Yanhui Hu,
  • Sue Young Oh,
  • Daehan Lee,
  • A. Vipin Menon,
  • Seok Jun Moon,
  • Norbert Perrimon,
  • Jin-Wu Nam,
  • Jiwon Shim

DOI
https://doi.org/10.1038/s41467-020-18135-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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How the Drosophila lymph gland hemocytes develop and are regulated at a single-cell level is unclear. Here, the authors use single-cell RNA sequencing to show heterogeneity of developing hemocytes in the lymph gland and how they react to wasp infestation, and compare hemocytes from two independent origins.