Nature Communications (Feb 2021)

Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy

  • Carla Kirschbaum,
  • Kim Greis,
  • Eike Mucha,
  • Lisa Kain,
  • Shenglou Deng,
  • Andreas Zappe,
  • Sandy Gewinner,
  • Wieland Schöllkopf,
  • Gert von Helden,
  • Gerard Meijer,
  • Paul B. Savage,
  • Mateusz Marianski,
  • Luc Teyton,
  • Kevin Pagel

DOI
https://doi.org/10.1038/s41467-021-21480-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 7

Abstract

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Glycolipids are glycoconjugates with important biological functions, but techniques for their analysis are deficient. Here, the authors report the use of cryogenic gas-phase infrared spectroscopy to investigate isomerism in a set of immunologically relevant glycolipids, and show that their structural features can be accurately resolved based on a narrow spectral fingerprint region.