Potentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor

Abstract

Recombinant human granulocyte colony-stimulating factor (G-CSF) is commonly used to accelerate recovery of neutropenia in patients with marrow suppression. We hereby report a patient with systemic lupus erythematosus (SLE) who developed diffuse lupus nephritis and impending cytokine storm after G-CSF therapy. The exact mechanisms by which G-CSF leads to lupus flares remains enigmatic. Increased neutrophil apoptosis and release of cytokines have been postulated. The use of G-CSF in patients with autoimmune disease should be cautious.

Keywords

• granulocyte colony-stimulating factor
• systemic lupus erythematosus
• leucopenia
• cytokine storm syndrome
• azathioprine