Dynamics of endothelial dysfunction indices before and after operation in patients with varicose disease of the lower extremities

Abstract

The aim of the study is to examine the correlation between the endothelial dysfunction indices and the clinical class of the disease before and after the operation in patients with varicose disease of the lower extremities. Materials and methods. In total, 69 patients with varicose disease of the lower extremities were examined, with preoperative and long-term postoperative measurements of homocysteine, nitrotyrosine and eNOS by the immunoassay analysis. Results. The results of dynamic changes in endothelial dysfunction indices in 69 patients with varicose disease of the lower extremities, examined before and after an operation, were analyzed. A significant correlation between the mean values of homocysteine, nitrotyrosine and eNOS with the clinical class of lower extremity varicose vein disease (LEVVD) has been determined. Conclusions. A significant decrease in the indices of homocysteine, nitrotyrosine and increased eNOS was observed long term following operation compared to the initial values before it. It has been established that the homocysteine values were relatively stronger correlated with the patient's age than with the LEVVD clinical class, and nitrotyrosine and eNOS were relatively higher correlated with the LEVVD class than with the patients’ age.

Keywords

• lower extremity
• varicose vein
• endothelium vascular