The role of liver microenvironment cells in colorectal cancer liver metastasis

Abstract

The liver is the most common site of metastasis in patients with colorectal cancer(CRC). The liver microenvironment is a diverse assemblage of cells, which has their own unique biological characteristics and functions, supplemented by the interaction between cells, which jointly regulate the tumor microenvironment and play significant role in the occurrence and development of CRC liver metastasis. Consequently, a thorough investigation of the molecular mechanisms underlying CRC liver metastasis is imperative for comprehension of tumor progression, prediction of metastasis risk, and the development of innovative therapeutic strategy. This paper delved into the cellular constituents of the liver tumor microenvironment, elucidating the roles and influences of diverse cell types in the process of CRC liver metastasis, offering fresh insights and strategies for the diagnosis and management of CRC liver metastasis.

Keywords

• |colorectal cancer liver metastasis|tumor microenvironment|hepatic stellate cell(hepsc)|liver sinusoidal endothelial cell(lsec)|kupffer cell(kc)|neutrophil|macrophage|myeloid-derived suppressor cell(mdsc)