Department of Bee Research, Plant Protection Research Institute, Agricultural Research Centre, Giza 12627, Egypt
Shaden A. M. Khalifa
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-106 91 Stockholm, Sweden
Mohamed H. Elashal
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt
Syed G. Musharraf
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Aamer Saeed
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Alfi Khatib
Pharmacognosy Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang Darul Makmur, Malaysia
Haroon Elrasheid Tahir
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Xiaobo Zou
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Yahya Al Naggar
General Zoology, Institute for Biology, Martin Luther University Halle-Wittenberg, Hoher Weg 8, 06120 Halle, Germany
Arshad Mehmood
Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China
Kai Wang
Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China
Hesham R. El-Seedi
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt
Bee venom (BV) is a typical toxin secreted by stingers of honeybee workers. BV and BV therapy have long been attractive to different cultures, with extensive studies during recent decades. Nowadays, BV is applied to combat several skin diseases, such as atopic dermatitis, acne vulgaris, alopecia, vitiligo, and psoriasis. BV is used extensively in topical preparations as cosmetics and used as dressing for wound healing, as well as in facemasks. Nevertheless, the safety of BV as a therapeutic choice has always been a concern due to the immune system reaction in some people due to BV use. The documented unfavorable impact is explained by the fact that the skin reactions to BV might expand to excessive immunological responses, including anaphylaxis, that typically resolve over numerous days. This review aims to address bee venom therapeutic uses in skin cosmetics.
