Urine metabolites associated with cardiovascular effects from exposure of size-fractioned particulate matter in a subway environment: A randomized crossover study

Yannan Zhang; Mengtian Chu; Jingyi Zhang; Junchao Duan; Dayu Hu; Wenlou Zhang; Xuan Yang; Xu Jia; Furong Deng; Zhiwei Sun

Environment International (Sep 2019)

Urine metabolites associated with cardiovascular effects from exposure of size-fractioned particulate matter in a subway environment: A randomized crossover study

Yannan Zhang,
Mengtian Chu,
Jingyi Zhang,
Junchao Duan,
Dayu Hu,
Wenlou Zhang,
Xuan Yang,
Xu Jia,
Furong Deng,
Zhiwei Sun

Affiliations

Yannan Zhang: Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China
Mengtian Chu: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China
Jingyi Zhang: Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China
Junchao Duan: Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China; Corresponding authors at: School of Public Health, Capital Medical University, Beijing 100069, PR China.
Dayu Hu: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China
Wenlou Zhang: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China
Xuan Yang: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China
Xu Jia: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China
Furong Deng: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China; Correspondence to: F. Deng, School of Public Health, Peking University, Beijing 100191, PR China.
Zhiwei Sun: Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China; Corresponding authors at: School of Public Health, Capital Medical University, Beijing 100069, PR China.

Journal volume & issue: Vol. 130

Abstract

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Background: Ambient particulate matter (PM) is closely associated with morbidity and mortality from cardiovascular disease. Urine metabolites can be used as a non-invasive means to explore biological mechanisms for such associations, yet has not been performed in relation to different sizes of PM. In this randomized crossover study, we used metabolomics approach to explore the urine biomarkers linked with cardiovascular effects after PM exposure in a subway environment. Methods and results: Thirty-nine subjects were exposed to PM for 4 h in subway system, with either a respirator intervention phase (RIP) with facemask and no intervention phase (NIP) in random order with a 2-week washout period. Electrocardiogram (ECG) parameters and ambulatory blood pressure (BP) were monitored during the whole riding period and urine samples were collected for metabolomics analysis. After exposure to PM for 4 h in subway system, 4 urine metabolites in male and 7 urine metabolites in female were screened out by UPLC/Q-TOF MS/MS-based metabolomics approach. Cardiovascular parameters (HRV and HR) predominantly decreased in response to all size-fractions of PM and were more sensitive in response to different size-fractioned PM in males than females. Besides LF/HF, most of the HRV indices decrease induced by the increase of all size-fractioned PM while PM1.0 was found as the most influential one on indicators of cardiovascular effects and urine metabolites both genders. Prolyl-arginine and 8-OHdG were found to have opposing role regards to HRV and HR in male. Conclusion: Our data indicated that short-term exposure to PM in a subway environment may increase the risk of cardiovascular disease as well as affect urine metabolites in a size dependent manner (besides PM0.5), and male were more prone to trigger the cardiovascular events than female after exposure to PM; whereas wearing facemask could effectively reduce the adverse effects caused by PM. Keywords: Particulate matter, Urine metabolites, Cardiovascular effects, Personal intervention, 8-OHdG

Published in Environment International

ISSN: 0160-4120 (Print)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/environment-international

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