Nature Communications (Jul 2021)

Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells

  • Wei-Ching Chen,
  • Minh D. To,
  • Peter M. K. Westcott,
  • Reyno Delrosario,
  • Il-Jin Kim,
  • Mark Philips,
  • Quan Tran,
  • Saumya R. Bollam,
  • Hani Goodarzi,
  • Nora Bayani,
  • Olga Mirzoeva,
  • Allan Balmain

DOI
https://doi.org/10.1038/s41467-021-24498-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Kras is frequently mutated in lung cancer and two isoforms are generated via alternative splicing. Here, the authors show that the two isoforms have divergent roles in cancer stem cells and the main tumour cell population, which are regulated by hypoxia and endoplasmic reticulum stress.