Nature Communications (Apr 2019)
Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
- Lei Gao,
- Yong Hu,
- Yahui Tian,
- Zhenzhen Fan,
- Kun Wang,
- Hongdan Li,
- Qian Zhou,
- Guandi Zeng,
- Xin Hu,
- Lei Yu,
- Shiyu Zhou,
- Xinyuan Tong,
- Hsinyi Huang,
- Haiquan Chen,
- Qingsong Liu,
- Wanting Liu,
- Gong Zhang,
- Musheng Zeng,
- Guangbiao Zhou,
- Qingyu He,
- Hongbin Ji,
- Liang Chen
Affiliations
- Lei Gao
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Yong Hu
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Yahui Tian
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Zhenzhen Fan
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Kun Wang
- Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences
- Hongdan Li
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Qian Zhou
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Guandi Zeng
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Xin Hu
- The University of Texas Health Science Center at Houston (UTHealth)
- Lei Yu
- Beijing Tongren Hospital, Capital Medical University
- Shiyu Zhou
- State Key Laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Xinyuan Tong
- State Key Laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Hsinyi Huang
- State Key Laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Haiquan Chen
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Qingsong Liu
- High Magnetic Field Laboratory, Chinese Academy of Sciences
- Wanting Liu
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Gong Zhang
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Musheng Zeng
- Department of Experimental Research, Sun Yat-sen University Cancer Center
- Guangbiao Zhou
- State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Qingyu He
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Hongbin Ji
- State Key Laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Liang Chen
- Key Laboratory of Functional Protein Research of Guangdong Higher Education, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- DOI
- https://doi.org/10.1038/s41467-019-09295-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The tumor suppressor GATA4 is frequently epigenetically silenced in lung cancer. In this study, Gao et al. demonstrate that GATA4 regulates the expression of TGFBR2 and that TGFRB1 inhibitors can synergise with chemotherapeutics to inhibit the growth of GATA4-deficient tumors in mice.
