Emergent dolutegravir resistance in integrase-naïve, treatment experienced patients from Zimbabwe

Abstract

We report two cases of dolutegravir (DTG) resistance in highly treatment experienced patients. Monitoring for treatment failure and adherence support is important in highly treatment experienced patients taking DTG. What this study adds: Dolutegravir is the mainstay of HIV treatment programmes and emergence of drug resistance to DTG is of public health relevance.

Keywords

• hiv drug resistance
• dolutegravir
• integrase strand inhibitor
• antiretroviral treatment
• hiv