Nature Communications (Jan 2023)
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
- Benedicte Sjo Tislevoll,
- Monica Hellesøy,
- Oda Helen Eck Fagerholt,
- Stein-Erik Gullaksen,
- Aashish Srivastava,
- Even Birkeland,
- Dimitrios Kleftogiannis,
- Pilar Ayuda-Durán,
- Laure Piechaczyk,
- Dagim Shiferaw Tadele,
- Jørn Skavland,
- Panagotis Baliakas,
- Randi Hovland,
- Vibeke Andresen,
- Ole Morten Seternes,
- Tor Henrik Anderson Tvedt,
- Nima Aghaeepour,
- Sonia Gavasso,
- Kimmo Porkka,
- Inge Jonassen,
- Yngvar Fløisand,
- Jorrit Enserink,
- Nello Blaser,
- Bjørn Tore Gjertsen
Affiliations
- Benedicte Sjo Tislevoll
- Centre for Cancer Biomarkers (CCBIO), Department of Clinical Science, University of Bergen
- Monica Hellesøy
- Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Helse Bergen HF
- Oda Helen Eck Fagerholt
- Centre for Cancer Biomarkers (CCBIO), Department of Clinical Science, University of Bergen
- Stein-Erik Gullaksen
- Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Helse Bergen HF
- Aashish Srivastava
- Genome Core Facility, Clinical Laboratory, K2 Haukeland University Hospital
- Even Birkeland
- The Proteomics Facility of the University of Bergen (PROBE), University of Bergen
- Dimitrios Kleftogiannis
- Centre for Cancer Biomarkers (CCBIO), Department of Clinical Science, University of Bergen
- Pilar Ayuda-Durán
- Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital
- Laure Piechaczyk
- Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital
- Dagim Shiferaw Tadele
- Department of Molecular Genetics, Division of Laboratory Medicine, Oslo University Hospital
- Jørn Skavland
- Centre for Cancer Biomarkers (CCBIO), Department of Clinical Science, University of Bergen
- Panagotis Baliakas
- Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University
- Randi Hovland
- Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital
- Vibeke Andresen
- Centre for Cancer Biomarkers (CCBIO), Department of Clinical Science, University of Bergen
- Ole Morten Seternes
- Department of Pharmacy, UiT-The Arctic University of Norway
- Tor Henrik Anderson Tvedt
- Department of Hematology, Oslo University Hospital
- Nima Aghaeepour
- Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine
- Sonia Gavasso
- Centre for Cancer Biomarkers (CCBIO), Department of Clinical Science, University of Bergen
- Kimmo Porkka
- Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center
- Inge Jonassen
- Centre for Cancer Biomarkers and Computational Biology Unit, Department of Informatics, University of Bergen
- Yngvar Fløisand
- Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
- Jorrit Enserink
- Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital
- Nello Blaser
- Department of Informatics, University of Bergen
- Bjørn Tore Gjertsen
- Centre for Cancer Biomarkers (CCBIO), Department of Clinical Science, University of Bergen
- DOI
- https://doi.org/10.1038/s41467-022-35624-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
The molecular mechanisms underlying response to chemotherapy in Acute myeloid leukemia (AML) remain to be explored. Here, the authors perform 36-dimensional mass cytometry in 32 AML patients during intensive chemotherapy and suggest functional signalling analysis for prognosis prediction early after treatment in AML.
